Gene information
Official symbol ELANE
Official full name elastase, neutrophil expressed
Gene type protein-coding gene
Chromosome19p13.3
Alias symbolNE; HNE; HLE
Previous symbolELA2
Gene familyGranule associated serine proteases of immune defence; Complement system regulators and receptors
Resources
Entrez Gene 1991
HGNC HGNC:3309
Ensembl ENSG00000197561
Vega OTTHUMG00000181839
UCSC uc002lqb.4
GO terms: 120 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001906 cell killing GO Biological Processes -7.45870005 11 More
GO:0001909 leukocyte mediated cytotoxicity GO Biological Processes -5.30042050 7 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002437 inflammatory response to antigenic stimulus GO Biological Processes -7.96781477 8 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002444 myeloid leukocyte mediated immunity GO Biological Processes -7.71730059 9 More
GO:0002446 neutrophil mediated immunity GO Biological Processes -8.04833674 7 More
GO:0002523 leukocyte migration involved in inflammatory response GO Biological Processes -8.96527714 10 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002691 regulation of cellular extravasation GO Biological Processes -7.79276545 8 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005766 primary lysosome GO Cellular Components -4.39854337 10 More
GO:0005775 vacuolar lumen GO Cellular Components -10.7475427 18 More
GO:0006518 peptide metabolic process GO Biological Processes -2.74792434 15 More
GO:0006873 cellular ion homeostasis GO Biological Processes -10.3574947 26 More
GO:0006874 cellular calcium ion homeostasis GO Biological Processes -8.17100062 15 More
GO:0006875 cellular metal ion homeostasis GO Biological Processes -10.3879696 23 More
GO:0006909 phagocytosis GO Biological Processes -7.82039874 17 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009620 response to fungus GO Biological Processes -9.57465113 11 More
GO:0017053 transcription repressor complex GO Cellular Components -4.12949610 12 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019730 antimicrobial humoral response GO Biological Processes -11.7829906 16 More
GO:0019731 antibacterial humoral response GO Biological Processes -4.08950781 6 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0030003 cellular cation homeostasis GO Biological Processes -9.22969208 24 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032682 negative regulation of chemokine production GO Biological Processes -6.18749803 9 More
GO:0032757 positive regulation of interleukin-8 production GO Biological Processes -14.6396218 15 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035578 azurophil granule lumen GO Cellular Components -4.57928114 8 More
GO:0035580 specific granule lumen GO Cellular Components -14.6396218 15 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042581 specific granule GO Cellular Components -15.6202777 22 More
GO:0042582 azurophil granule GO Cellular Components -4.39854337 10 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043603 cellular amide metabolic process GO Biological Processes -1.84597279 17 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045335 phagocytic vesicle GO Cellular Components -3.63275570 16 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050801 ion homeostasis GO Biological Processes -12.0812968 60 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050832 defense response to fungus GO Biological Processes -7.96091962 9 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050922 negative regulation of chemotaxis GO Biological Processes -8.57011989 17 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051702 biological process involved in interaction with symbiont GO Biological Processes -12.570571 16 More
GO:0051873 killing by host of symbiont cells GO Biological Processes -7.35623750 7 More
GO:0055065 metal ion homeostasis GO Biological Processes -12.9426258 29 More
GO:0055074 calcium ion homeostasis GO Biological Processes -10.3600555 19 More
GO:0055080 cation homeostasis GO Biological Processes -11.5718912 30 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide GO Biological Processes -7.52692728 10 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070269 pyroptosis GO Biological Processes -4.13020121 7 More
GO:0070942 neutrophil mediated cytotoxicity GO Biological Processes -5.46227840 4 More
GO:0070943 neutrophil-mediated killing of symbiont cell GO Biological Processes -5.46227840 4 More
GO:0070944 neutrophil-mediated killing of bacterium GO Biological Processes -5.46227840 4 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0072503 cellular divalent inorganic cation homeostasis GO Biological Processes -7.40235615 16 More
GO:0072507 divalent inorganic cation homeostasis GO Biological Processes -10.6286093 21 More
GO:0098771 inorganic ion homeostasis GO Biological Processes -12.1048319 31 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell GO Biological Processes -9.55155535 14 More
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell GO Biological Processes -8.04419623 7 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04613 Neutrophil extracellular trap formation KEGG Pathway -12.8071279 20 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05322 Systemic lupus erythematosus KEGG Pathway -4.88971598 10 More
Drug-Gene interaction
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Related drugs: 8 records
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
NM_001972.4:c.-761G>A genomics myocardial infarction[diagnosis] myocardial infarction Schonfelder J et al. Pharmacogenet Genomics. 2007
NM_001972.4:c.[-761G>A;4890C>A] genomics myocardial infarction[diagnosis] myocardial infarction Schonfelder J et al. Pharmacogenet Genomics. 2007
neutrophil elastase proteomics ischemia reperfusion injury[prognosis (bad)] acute myocardial infarction Nishida Y et al. Kokyu To Junkan. 1992
neutrophil elastase proteomics death[prognosis (bad)] acute myocardial infarction Shimai S et al. Jpn Circ J. 1989
neutrophil elastase proteomics ulinastatin[treatment (pharmacotherapy)] acute myocardial infarction Shimai S et al. Jpn Circ J. 1989
neutrophil elastase proteomics complication[prognosis (bad)] acute myocardial infarction Lechleitner P et al. Z Kardiol. 1993
neutrophil elastase proteomics ventricular septal rupture[prognosis (bad)] acute myocardial infarction Kameda K et al. Circ J. 2006
neutrophil elastase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kameda K et al. Circ J. 2006
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